Indications and Dosage of Mirtazapine 15mg

Effective Daily Dose

• Usually between 15 and 45 mg per day
• Starting dose: 15 mg or 30 mg
• Duration of action: Effect usually starts after 1-2 weeks
• Evaluation period: After 2-4 weeks a positive response should be visible. If the effect is insufficient the dose can be increased.
• No response after 4 additional weeks? Then treatment should be stopped.

Duration of Treatment

• Patients with depression should be treated for at least 6 months to ensure complete freedom from symptoms.
• Stopping mirtazapine 25mg? This should be done gradually to avoid withdrawal symptoms.

Specific Patient Groups

Elderly

• Recommended dosage is the same as for adults .
• Dosage increases should be done under close supervision for a safe and effective response.

Pediatric Patients (Under 18 years)

• Not recommended.
• No proven effectiveness in clinical studies and safety risks.

Hepatic impairment

• Reduced clearance in hepatic impairment → dose adjustment may be necessary.
• In severe hepatic impairment, no studies have been performed, caution is advised.

Method of administration

• Half-life: 20-40 hours → once daily administration recommended.
• Preferably in the evening before going to bed .
• Alternative: Two divided doses per day (morning and evening, higher dose in the evening).
• Intake:
  • Take orally with liquid
  • Do not chew , swallow immediately.